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LD50 has not been established because researchers could not achieve lethal doses in standard protocols 1

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Three-times-weekly dosing (often Monday, Wednesday, Friday) further reduces usage and extends supply to approximately 16 weeks at 2mg per dose

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Across the six published trials, the most common adverse events were headache, mild gastrointestinal effects (diarrhea, flatulence, nausea), nasopharyngitis, fatigue, dizziness, and mild injection-site reactions